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Article

Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders.

Molecular psychiatry - 1 Jun 2021

Byrne Enda M, Zhu Zhihong, Qi Ting, Skene Nathan G, Bryois Julien, Pardinas Antonio F, Stahl Eli, Smoller Jordan W, Rietschel Marcella, Owen Michael J, Walters James T R, O'Donovan Michael C, McGrath John G, Hjerling-Leffler Jens, Sullivan Patrick F, Goddard Michael E, Visscher Peter M, Yang Jian, Wray Naomi R

Abstract excerpt

Substantial genetic liability is shared across psychiatric disorders but less is known about risk variants that are specific to a given disorder. We used multi-trait conditional and joint analysis (mtCOJO) to adjust GWAS summary statistics of one disorder for the effects of genetically correlated traits to identify putative disorder-specific SNP associations. We applied mtCOJO to summary statistics for five...

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Identifiers

PMID: 32398722
DOI: 10.1038/s41380-020-0705-9
PMCID: PMC7657979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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