Article
Association between ADH1B and ADH1C polymorphisms and the risk of head and neck squamous cell carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jun 2015
Ji Yong Bae, Lee Seung Hwan, Kim Kyung Rae, Park Chul Won, Song Chang Myeon, Park Byung Lae, Shin Hyoung Doo, Tae Kyung
Abstract excerpt
Alcohol consumption is one of the major risk factors for head and neck squamous cell carcinoma (HNSCC), and the alcohol dehydrogenase (ADH) family proteins are key enzymes in ethanol metabolism. We examined the associations between single nucleotide polymorphisms (SNPs) of ADH1B and ADH1C and the risk of HNSCC. We analyzed six SNPS of ADH1B, namely -992C > G, -957C > A, +3170A>G, +3377G>T, +3491G>A, and...
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