Article
Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions.
Nature genetics - 1 Oct 2012
Wu Chen, Kraft Peter, Zhai Kan, Chang Jiang, Wang Zhaoming, Li Yun, Hu Zhibin, He Zhonghu, Jia Weihua, Abnet Christian C, Liang Liming, Hu Nan, Miao Xiaoping, Zhou Yifeng, Liu Zhihua, Zhan Qimin, Liu Yu, Qiao Yan, Zhou Yuling, Jin Guangfu, Guo Chuanhai, Lu Changdong, Yang Haijun, Fu Jianhua, Yu Dianke, Freedman Neal D, Ding Ti, Tan Wen, Goldstein Alisa M, Wu Tangchun, Shen Hongbing, Ke Yang, Zeng Yixin, Chanock Stephen J, Taylor Philip R, Lin Dongxin
Abstract excerpt
We conducted a genome-wide association study (GWAS) and a genome-wide gene-environment interaction analysis of esophageal squamous-cell carcinoma (ESCC) in 2,031 affected individuals (cases) and 2,044 controls with independent validation in 8,092 cases and 8,620 controls. We identified nine new ESCC susceptibility loci, of which seven, at chromosomes 4q23, 16q12.1, 17q21, 22q12, 3q27, 17p13 and 18p11, had a...
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