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Article

The ALDH7A1 genetic polymorphisms contribute to development of esophageal squamous cell carcinoma.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Dec 2014

Wang Haiyong, Tong Lei, Wei Jinyu, Pan Wenting, Li Lichao, Ge Yunxia, Zhou Liqing, Yuan Qipeng, Zhou Changchun, Yang Ming

Abstract excerpt

Although the entire etiology of esophageal squamous cell carcinoma (ESCC) is still unclear, alcohol drinking has been identified as a major environmental risk factor. The aldehyde dehydrogenase (ALDH) superfamily members are major enzymes involved in the alcohol-metabolizing pathways. Accumulating evidences demonstrated that ALDH7A1, one of ALDH superfamily members, degrades and detoxifies acetaldehyde generated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25213698
DOI: 10.1007/s13277-014-2590-9

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