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Article

Replication study of ESCC susceptibility genetic polymorphisms locating in the ADH1B-ADH1C-ADH7 cluster identified by GWAS.

PloS one - 1 Jan 2014

Wang Jiwen, Wei Jinyu, Xu Xiaoling, Pan Wenting, Ge Yunxia, Zhou Changchun, Liu Chao, Gao Jia, Yang Ming, Mao Weimin

Abstract excerpt

China was one of the countries with highest esophageal squamous cell carcinoma (ESCC) incidence and mortality worldwide. Alcohol drinking has been identified as a major environmental risk-factor related to ESCC. The alcohol dehydrogenase (ADH) family are major enzymes involved in the alcohol-metabolizing pathways, including alcohol dehydrogenase 1B (ADH1B) and ADH1C. Interestingly, ADH1B and ADH1C genes locate...

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Identifiers

PMID: 24722735
DOI: 10.1371/journal.pone.0094096
PMCID: PMC3983154

Genes

ADH7

Provenance

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