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Article

Oocyte ageing and its cellular basis

1 Jan 2012

Abstract excerpt

Aneuploidy is extremely high in aged human oocytes. Its cellular origin has been elusive. Trisomy data implicate predominantly meiosis I errors in the genesis of oocyte aneuploidy. Susceptible recombination patterns increase risks for nondisjunction. Cytogenetic analyses of aged human oocytes and embryos from assisted reproduction (ART) suggest that aneuploidy primarily relates to precocious chromatid separation....

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PMID: 23417406
DOI: 10.1387/ijdb.120141ue

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