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Why is Chromosome Segregation Error in Oocytes Increased With Maternal Aging?

1 Oct 2011

Abstract excerpt

It is well documented that female fertility is decreased with advanced maternal age due to chromosome abnormality in oocytes. Increased chromosome missegregation is mainly caused by centromeric cohesion reduction. Other factors such as weakened homologous recombination, improper spindle organization, spindle assembly checkpoint (SAC) malfunction, chromatin epigenetic changes, and extra-oocyte factors may also...

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PMID: 22013190
DOI: 10.1152/physiol.00020.2011

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