Article
Condensin function at centromere chromatin facilitates proper kinetochore tension and ensures correct mitotic segregation of sister chromatids.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Sept 2007
Yong-Gonzalez Vladimir, Wang Bi-Dar, Butylin Pavel, Ouspenski Ilia, Strunnikov Alexander
Abstract excerpt
The condensin complex is essential for sister chromatid segregation in eukaryotic mitosis. Nevertheless, in budding yeast, condensin mutations result in massive mis-segregation of chromosomes containing the nucleolar organizer, while other chromosomes, which also contain condensin binding sites, remain genetically stable. To investigate this phenomenon we analyzed the mechanism of the cell-cycle arrest elicited...
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