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Article

Malonylation of histone H2A at lysine 119 inhibits Bub1-dependent H2A phosphorylation and chromosomal localization of shugoshin proteins.

Scientific reports - 16 May 2018

Ishiguro Tadashi, Tanabe Kana, Kobayashi Yuki, Mizumoto Shinsuke, Kanai Motomu, Kawashima Shigehiro A

Abstract excerpt

Post-translational modifications of histones, such as acetylation and phosphorylation, are highly conserved in eukaryotes and their combination enables precise regulation of many cellular functions. Recent studies using mass spectrometry have revealed various non-acetyl acylations in histones, including malonylation and succinylation, which change the positive charge of lysine into a negative one. However, the...

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Identifiers

PMID: 29769606
DOI: 10.1038/s41598-018-26114-z
PMCID: PMC5956101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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