Article
In vivo calcium elevations in thymocytes with T cell receptors that are specific for self ligands.
Science (New York, N.Y.) - 3 Jul 1992
Nakayama T, Ueda Y, Yamada H, Shores E W, Singer A, June C H
Abstract excerpt
Selection of the T cell receptor (TCR) repertoire in the thymus probably involves TCR-mediated signals transduced in developing thymocytes after interaction with thymic stromal cells bearing self ligands. TCR-transduced signals should have identifiable consequences that would distinguish thymocyt...
Topics
- Animals
- CD4 Antigens
- CD8 Antigens
- Calcium
- Female
- Male
- Mice
- Mice, Transgenic
- Phenotype
- Receptors, Antigen, T-Cell
- Sex Characteristics
- Signal Transduction
- Spleen
- T-Lymphocyte Subsets
- T-Lymphocytes
- Thymus Gland