Article
In vivo calcium elevations in thymocytes with T cell receptors that are specific for self ligands.
Science (New York, N.Y.) - 3 Jul 1992
Nakayama T, Ueda Y, Yamada H, Shores E W, Singer A, June C H
Abstract excerpt
Selection of the T cell receptor (TCR) repertoire in the thymus probably involves TCR-mediated signals transduced in developing thymocytes after interaction with thymic stromal cells bearing self ligands. TCR-transduced signals should have identifiable consequences that would distinguish thymocytes whose TCRs have been engaged by self ligands from those whose TCRs have not. Among thymocytes expressing a...
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