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Article

Naive CD4+ T cells from lupus-prone Fas-intact MRL mice display TCR-mediated hyperproliferation due to intrinsic threshold defects in activation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2005

Zielinski Christina E, Jacob Simon N, Bouzahzah Farida, Ehrlich Barbara E, Craft Joe

Abstract excerpt

Autoreactive T cell activation is a consistent feature of murine lupus; however, the mechanism of such activation remains unclear. We hypothesized that naive CD4+ T cells in lupus have a lower threshold of activation through their TCR-CD3 complex that renders them more susceptible to stimulation with self-Ags. To test this hypothesis, we compared proliferation, IL-2 production, and single cell calcium signaling...

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Identifiers

PMID: 15814741
DOI: 10.4049/jimmunol.174.8.5100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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