Article

Developmental self-reactivity determines the pathogenic Tc17 differentiation potential of naive CD8+ T cells by adjusting endogenous SMAD3 expression

2023-05-01

Abstract excerpt

<title>Abstract</title> The differentiation of naive CD8+ T cells into effector cells is important for establishing immunity. However, the effect of heterogeneous naive CD8+ T cell populations is not fully understood. Here, we demonstrate that steady-state naive CD8+ T cells are composed of functionally heterogeneous subpopulations that differ in their ability to differentiate...

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Literature Corpus work: e4d26e67-53c4-5ca3-ab70-9c9927f7ceea
DOI: 10.21203/rs.3.rs-2827447/v1

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