Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Mar 2026

Zhao Wei, Hao Qian, Gan Yu, Tong Jing, Chen Xiaodan, Tan Shuran, Ruan Ruiwen, Huang Yingdan, Cao Mingming, Deng Jun, Han Tao, Shi Getao, Gao Bo, Zhang Yu, Zhou Xiang

Abstract excerpt

Mutation of the tumor suppressor gene TP53 promotes ovarian cancer progression and therapeutic resistance. Whether mutant p53 (mtp53) regulates alternative splicing and how this regulation can be exploited for cancer therapy remain unclear. Here, small nuclear ribonucleoprotein D2 polypeptide (SNRPD2) as a binding partner of mtp53 is identified. SNRPD2 is highly expressed in ovarian cancer and associated with an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exosomes

Share to TP53 gene

Share to Mutation

Share to Ovarian Neoplasms

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 41560375
DOI: 10.1002/advs.202513369
PMCID: PMC13042878

Genes

SNRPD2
OTUD3
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer.PMID 41560375Read ↗

Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5.Semantic proximity Read ↗

Pan-cancer Analysis Reveals the Small Nuclear Ribonucleoprotein Polypeptide C (SNRPC) Its Significance in Human CancersSemantic proximity Read ↗

The immunomodulation effects of small nuclear ribonucleoprotein polypeptide G (SNRPG) in human brain tumorsSemantic proximity Read ↗

Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein.Semantic proximity Read ↗

Dual regulation of p53 by the ribosome maturation factor SBDSSemantic proximity Read ↗

TRMT1-Mediated tRNA m22G Modification Drives Osimertinib Resistance via the ATXN3/USP25 Axis in Lung AdenocarcinomaSemantic proximity Read ↗

The RNA helicase DDX53 (CAGE) contributes to RNA metabolism in a human germ cell modelSemantic proximity Read ↗

Therapeutic potential of combating cancer by restoring wild-type p53 through mRNA nanodelivery.Semantic proximity Read ↗

Cisplatin-induced PANDAR-Chemo-EVs contribute to a more aggressive and chemoresistant ovarian cancer phenotype through the SRSF9-SIRT4/SIRT6 axis.Semantic proximity Read ↗

Potential oncogenic roles of mutant-p53-derived exosomes in the tumor-host interaction of head and neck cancers.Semantic proximity Read ↗

Small Nuclear Ribonucleoprotein Polypeptide N Accelerates Malignant Progression and Poor Prognosis in Colorectal Cancer Transcriptionally Regulated by E2F8Semantic proximity Read ↗

MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.