Article
Inhibition of nonsense-mediated decay rescues p53β/γ isoform expression and activates the p53 pathway in MDM2-overexpressing and select p53-mutant cancers.
The Journal of biological chemistry - 1 Nov 2021
Gudikote Jayanthi P, Cascone Tina, Poteete Alissa, Sitthideatphaiboon Piyada, Wu Qiuyu, Morikawa Naoto, Zhang Fahao, Peng Shaohua, Tong Pan, Li Lerong, Shen Li, Nilsson Monique, Jones Phillip, Sulman Erik P, Wang Jing, Bourdon Jean-Christophe, Johnson Faye M, Heymach John V
Abstract excerpt
Inactivation of p53 is present in almost every tumor, and hence, p53-reactivation strategies are an important aspect of cancer therapy. Common mechanisms for p53 loss in cancer include expression of p53-negative regulators such as MDM2, which mediate the degradation of wildtype p53 (p53α), and inactivating mutations in the TP53 gene. Currently, approaches to overcome p53 deficiency in these cancers are limited....
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