Article

Inhibition of nonsense-mediated decay rescues functional p53β/γ isoforms in MDM2-amplified cancers

2020-04-07

Abstract excerpt

<h4>ABSTRACT</h4> Common mechanisms for p53 loss in cancer include expression of MDM2 or the human papilloma virus (HPV)-encoded E6 protein which both mediate degradation of wild-type (WT) p53 (p53α). Here, we show that two alternatively-spliced, functional, truncated isoforms of p53 (p53β and p53γ, containing exons 1-9 of the p53 gene) can be markedly upregulated by pharmacologic or genetic inhibition of nonsens...

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Literature Corpus work: fbaa3c11-7eb5-5b7e-a012-dbaa5bbfb7f8
DOI: 10.1101/2020.04.06.026955

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