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Epidermal cornification is preceded by the expression of a keratinocyte-specific set of pyroptosis-related genes

6 Dec 2017

Abstract excerpt

The homeostasis of the epidermis depends on keratinocyte differentiation and cornification, a mode of programmed cell death that does not elicit inflammation. Here, we report that cornification is associated with the expression of specific genes that control multiple steps of pyroptosis, another form of cell death that involves the processing and release of interleukin-1 family (IL1F) cytokines. Expression levels...

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PMID: 29234126
DOI: 10.1038/s41598-017-17782-4

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