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Article

Gasdermin D-mediated keratinocyte pyroptosis as a key step in psoriasis pathogenesis

7 Sept 2023

Abstract excerpt

Abstract Gasdermin D (GSDMD)-mediated pyroptosis has a significant pro-inflammation characteristic due to dramatic secretion of pro-inflammatory substances. However, its role remains unclear in psoriasis as one chronic inflammatory skin disorder with high prevalence. We found that N-terminal GSDMD (N-GSDMD) was aberrantly expressed in epidermis of skin lesion in psoriasis patients and imiquimod-induced...

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PMID: 37673869
DOI: 10.1038/s41419-023-06094-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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