Dysregulation of Specialized Delay/Interference-Dependent Working Memory Following Loss of Dysbindin-1A in Schizophrenia-Related Phenotypes.

doi:10.1038/npp.2016.282

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Article

Dysregulation of Specialized Delay/Interference-Dependent Working Memory Following Loss of Dysbindin-1A in Schizophrenia-Related Phenotypes.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2017

Petit Emilie I, Michalak Zuzanna, Cox Rachel, O'Tuathaigh Colm M P, Clarke Niamh, Tighe Orna, Talbot Konrad, Blake Derek, Joel Josephine, Shaw Alexander, Sheardown Steven A, Morrison Alastair D, Wilson Stephen, Shapland Ellen M, Henshall David C, Kew James N, Kirby Brian P, Waddington John L

Abstract excerpt

Dysbindin-1, a protein that regulates aspects of early and late brain development, has been implicated in the pathobiology of schizophrenia. As the functional roles of the three major isoforms of dysbindin-1, (A, B, and C) remain unknown, we generated a novel mutant mouse, dys-1A-/-, with selective loss of dysbindin-1A and investigated schizophrenia-related phenotypes in both males and females. Loss of...

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PMID: 27986973
DOI: 10.1038/npp.2016.282
PMCID: PMC5437891

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