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Article

H19 lncRNA alters methylation and expression of Hnf4α in the liver of metformin-exposed fetuses

7 Dec 2017

Abstract excerpt

Metformin is the most widely used anti-diabetic medication worldwide. However, human and animal studies suggest that prenatal metformin exposure may increase the risk of metabolic disorders in adult offspring, yet the underpinning mechanism remains unclear. Here we report that metformin-exposed mouse fetuses exhibit elevated expression of the H19 long noncoding RNA, which induces hypomethylation and increased...

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PMID: 29215608
DOI: 10.1038/cddis.2017.392

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