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Article

Exposure of pregnant mice to chlorpyrifos-methyl alters embryonic H19 gene methylation patterns.

Environmental toxicology - 1 Aug 2014

Shin Hyo-Sook, Seo Jong-Hun, Jeong Sang-Hee, Park Sung-Won, Park Youngil, Son Seong-Wan, Kim Jin Suk, Kang Hwan-Goo

Abstract excerpt

The aim of this study was to identify whether chlorpyrifos methyl (CPM) exposure during pregnancy leads to changes in the methylation patterns of H19 gene. CPM 4, 20, 100 mg/kg bw/day was administered to 4 pregnant mice per group between 7 and 12 days post coitum (d.p.c.). Pregnant mice were killed at 13 d.p.c. The genomic methylation in primordial germ cells (PGCs) and fetal organs (the liver, intestine, and...

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Identifiers

PMID: 23125134
DOI: 10.1002/tox.21820

Genes

CPM
CAST
IGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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