Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver

4 Dec 2023

Abstract excerpt

Hepatocyte Nuclear Factor 4α (HNF4α), a master regulator of hepatocyte differentiation, is regulated by two promoters (P1 and P2) which drive the expression of different isoforms. P1-HNF4α is the major isoform in the adult liver while P2-HNF4α is thought to be expressed only in fetal liver and liver cancer. Here, we show that P2-HNF4α is indeed expressed in the normal adult liver at Zeitgeber time (ZT)9 and ZT21....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circadian rhythm and melatonin
Share to Diet and metabolism studies
Share to Diet, Metabolism, and Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38111711
DOI: 10.3389/fendo.2023.1266527

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liverPMID 38111711Read ↗

HNF4α isoforms: the fraternal twin master regulators of liver functionSemantic proximity Read ↗

HNF4α in Hepatocyte Health and DiseaseSemantic proximity Read ↗

Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinomaSemantic proximity Read ↗

Alternative human liver transcripts of TCF7L2 bind to the gluconeogenesis regulator HNF4α at the protein levelSemantic proximity Read ↗

The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesisSemantic proximity Read ↗

HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape.Semantic proximity Read ↗

Hepatocyte Nuclear Factor 4 Alpha: A Key Regulator of Liver Disease Pathology and Haemostatic DisordersSemantic proximity Read ↗

Hepatic circadian and differentiation factors control liver susceptibility for fatty liver disease and tumorigenesisSemantic proximity Read ↗

Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseasesSemantic proximity Read ↗

The molecular functions of hepatocyte nuclear factors - In and beyond the liver.Semantic proximity Read ↗

Hepatocyte nuclear factor 1, a transcription factor at the crossroads of glucose homeostasis.Semantic proximity Read ↗

Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networksSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.