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Article

In utero exposure to a maternal high-fat diet alters the epigenetic histone code in a murine model.

American journal of obstetrics and gynecology - 1 May 2014

Suter Melissa A, Ma Jun, Vuguin Patricia M, Hartil Kirsten, Fiallo Ariana, Harris R Alan, Charron Maureen J, Aagaard Kjersti M

Abstract excerpt

OBJECTIVE: Data from animal models show that in utero exposure to a maternal high-fat diet (HFD) renders susceptibility of these offspring to the adult onset of metabolic syndrome. We and others have previously shown that epigenetic modifications to histones may serve as a molecular memory of the in utero exposure, rendering the risk of adult disease. Because mice heterozygous for the Glut4 gene (insulin...

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Source

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Identifiers

PMID: 24793723
DOI: 10.1016/j.ajog.2014.01.045
PMCID: PMC4368445

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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