Article
Prenatal metformin exposure in mice programs the metabolic phenotype of the offspring during a high fat diet at adulthood.
PloS one - 1 Jan 2013
Salomäki Henriikka, Vähätalo Laura H, Laurila Kirsti, Jäppinen Norma T, Penttinen Anna-Maija, Ailanen Liisa, Ilyasizadeh Juan, Pesonen Ullamari, Koulu Markku
Abstract excerpt
AIMS: The antidiabetic drug metformin is currently used prior and during pregnancy for polycystic ovary syndrome, as well as during gestational diabetes mellitus. We investigated the effects of prenatal metformin exposure on the metabolic phenotype of the offspring during adulthood in mice. METHODS: Metformin (300 mg/kg) or vehicle was administered orally to dams on regular diet from the embryonic day E0.5 to...
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