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Metformin: Targeting the Metabolo-Epigenetic Link in Cancer Biology

2 Feb 2021

Abstract excerpt

Metabolism can directly drive or indirectly enable an aberrant chromatin state of cancer cells. The physiological and molecular principles of the metabolic link to epigenetics provide a basis for pharmacological modulation with the anti-diabetic biguanide metformin. Here, we briefly review how metabolite-derived chromatin modifications and the metabolo-epigenetic machinery itself are both amenable to modification...

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PMID: 33604300
DOI: 10.3389/fonc.2020.620641

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