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Article

Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells.

International journal of molecular sciences - 15 Nov 2013

Wu An-Guo, Wong Vincent Kam-Wai, Xu Su-Wei, Chan Wai-Kit, Ng Choi-In, Liu Liang, Law Betty Yuen-Kwan

Abstract excerpt

Emerging evidence indicates important protective roles being played by autophagy in neurodegenerative disorders through clearance of aggregate-prone or mutant proteins. In the current study, we aimed to identify autophagy inducers from Chinese medicinal herbs as a potential neuroprotective agent that enhances the clearance of mutant huntingtin and α-synuclein in PC-12 cells. Through intensive screening using the...

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PMID: 24248062
DOI: 10.3390/ijms141122618
PMCID: PMC3856081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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