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Article

Modulation of the prostaglandin-endoperoxide synthase 2 gene expression by variant haplotypes: influence of the 3'-untranslated region.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 30 Nov 2017

Piranda D N, Abreu R B V, Freitas-Alves D R, de Carvalho M A, Vianna-Jorge R

Abstract excerpt

The inducible inflammatory enzyme cycloxigenase-2 is up-regulated in cancer, and favors tumor progression. Cycloxigenase-2 is encoded by the prostaglandin-endoperoxide synthase 2 (PTGS2) gene, which presents sequence variations in the promoter region (PR) and in the 3'-untranslated region (3'-UTR). Different PR (rs689465, rs689466, rs20417) and 3'-UTR (rs5275) variants were generated by site-directed mutagenesis,...

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Share to 3' Untranslated Regions
Share to Cell Line, Tumor
Share to Cyclooxygenase 2
Share to Gene Expression Regulation, Neoplastic
Share to Luciferases
Share to MCF-7 Cells
Share to Mutagenesis, Site-Directed
Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 29211250
DOI: 10.1590/1414-431X20176546
PMCID: PMC5711006

Genes

PTGS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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