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A genetic variant in 3'-untranslated region of cyclooxygenases-2 gene is associated with risk of gastric cancer in a Chinese population.

DNA and cell biology - 1 Jul 2012

Li Huizhang, Ren Chuanli, Fan Zhining, Jin Guangfu, Du Jiangbo, Liu Li, Zhu Chen, Lu Feng, Ding Yanbing, Deng Bin, Hu Zhibin, Xu Yaochu, Shen Hongbing

Abstract excerpt

Cyclooxygenase-2 (COX-2) involves in multiple processes in carcinogenesis, including inflammation, apoptosis inhibition, immune response suppression, tumor cell invasion, and angiogenesis. COX-2 is overexpressed in various cancers, including gastric cancer. COX-2 is encoded by prostaglandin endoperoxide synthase 2 (PTGS2) gene. We hypothesized that potentially functional polymorphisms in PTGS2 may contribute to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22385256
DOI: 10.1089/dna.2012.1615

Genes

PTGS2

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