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Article

Cyclooxygenase-2 Gly587Arg variant is associated with differential enzymatic activity and risk of esophageal squamous-cell carcinoma.

Molecular carcinogenesis - 1 Oct 2009

Zhao Dan, Zhang Xuemei, Guo Yongli, Tan Wen, Lin Dongxin

Abstract excerpt

Functional SNPs in the COX-2 promoter region have been associated with susceptibility to esophageal squamous-cell carcinoma (ESCC). In this study, we investigated SNPs in the COX-2 coding region and their impact on risk of ESCC. The coding region of COX-2 in DNAs from 30 Han Chinese individuals was sequenced to identify SNPs. Different coding region variants identified were cloned and expressed in MCE-7 cells for...

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PMID: 19347867
DOI: 10.1002/mc.20543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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