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Article

A common single-nucleotide polymorphism in cyclooxygenase-2 disrupts microRNA-mediated regulation.

Oncogene - 22 Mar 2012

Moore A E, Young L E, Dixon D A

Abstract excerpt

Elevated expression of the prostaglandin synthase cyclooxygenase-2 (COX-2) is commonly observed in many chronic inflammatory diseases and cancer. However, the mechanisms allowing for pathogenic COX-2 overexpression are largely unknown. The gene for COX-2 (PTGS2) carries a common single-nucleotide polymorphism (SNP) at position 8473 (T8473C), in exon 10 that is associated with diseases in which COX-2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21822307
DOI: 10.1038/onc.2011.349
PMCID: PMC3454533

Genes

PTGS2

Variants

Provenance

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