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Article

Hypoxia-Inducible Factor 1-Alpha Gene Polymorphisms Impact Risk of Severespectrum Hypertensive Disorders of Pregnancy: A Case-Control Study.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Apr 2025

Baldauf Claire, Wei Chen, Pickering Trevor A, Grubbs Brendan, Gjessing Håkon, Wilson Melissa L

Abstract excerpt

Hypoxia-inducible factor 1-alpha (HIF-1α) regulates cellular responses to hypoxia. Overexpression of HIF-1α is associated with abnormal placental trophoblast invasion and hypertensive disorders of pregnancy. We evaluated the putative association between polymorphisms and haplotypes in parental and child HIF-1α genes and the risk of severe-spectrum hypertensive disorders of pregnancy. Case (N = 179) and control...

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Source

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Identifiers

PMID: 40085397
DOI: 10.1007/s43032-025-01835-5
PMCID: PMC11978723

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