Article
Microsatellite polymorphism in the heme oxygenase-1 promoter is associated with nonsevere and late-onset preeclampsia.
Hypertension (Dallas, Tex. : 1979) - 1 Jul 2014
Kaartokallio Tea, Klemetti Miira M, Timonen Anni, Uotila Jukka, Heinonen Seppo, Kajantie Eero, Kere Juha, Kivinen Katja, Pouta Anneli, Lakkisto Päivi, Laivuori Hannele
Abstract excerpt
Preeclampsia is a serious and phenotypically heterogeneous vascular pregnancy disorder. Heme oxygenase-1 (HO-1) is a stress response enzyme that may protect the maternal endothelium and facilitate adequate metabolic adaptation to pregnancy by its antioxidant and anti-inflammatory functions. HO-1 stress response is modulated by HO-1 gene (HMOX1) polymorphisms. Individuals with the long allele of a guanine-thymine...
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