Article
Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer.
Cancer discovery - 1 Mar 2018
Liu Hui, Murphy Charles J, Karreth Florian A, Emdal Kristina B, White Forest M, Elemento Olivier, Toker Alex, Wulf Gerburg M, Cantley Lewis C
Abstract excerpt
Triple-negative breast cancers (TNBC) are genetically characterized by aberrations in TP53 and a low rate of activating point mutations in common oncogenes, rendering it challenging in applying targeted therapies. We performed whole-exome sequencing (WES) and RNA sequencing (RNA-seq) to identify somatic genetic alterations in mouse models of TNBCs driven by loss of Trp53 alone or in combination with Brca1...
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