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Crucial and novel cancer drivers in a mouse model of triple-negative breast cancer.

Cancer genomics & proteomics - 1 Jan 2000

Johnson Jacob P S, Kumar Prashant, Koulnis Miroslav, Patel Milan, Simin Karl

Abstract excerpt

BACKGROUND: We previously developed a mouse model of breast cancer that mimics human triple-negative breast cancer (TNBC) by inactivating the Retinoblastoma (Rb), Transformation related protein 53 (p53), and Breast cancer 1 (Brca1) pathways in the mammary gland. Despite inactivation of all three tumor suppressors throughout the epithelium, low tumor multiplicity indicated that malignant carcinoma progression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24969692

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