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Article

Mass Spectrometry Imaging Establishes 2 Distinct Metabolic Phenotypes of Aldosterone-Producing Cell Clusters in Primary Aldosteronism.

Hypertension (Dallas, Tex. : 1979) - 1 Mar 2020

Sun Na, Meyer Lucie S, Feuchtinger Annette, Kunzke Thomas, Knösel Thomas, Reincke Martin, Walch Axel, Williams Tracy Ann

Abstract excerpt

Aldosterone-producing adenomas (APAs) are one of the main causes of primary aldosteronism and the most prevalent surgically correctable form of hypertension. Aldosterone-producing cell clusters (APCCs) comprise tight nests of zona glomerulosa cells, strongly positive for CYP11B2 (aldosterone synthase) in immunohistochemistry. APCCs have been suggested as possible precursors of APAs because they frequently carry...

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Identifiers

PMID: 31957522
DOI: 10.1161/HYPERTENSIONAHA.119.14041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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