Article
Sustained Activation of Rho GTPases Promotes a Synthetic Pulmonary Artery Smooth Muscle Cell Phenotype in Neprilysin Null Mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2018
Karoor Vijaya, Fini Mehdi A, Loomis Zoe, Sullivan Timothy, Hersh Louis B, Gerasimovskaya Evgenia, Irwin David, Dempsey Edward C
Abstract excerpt
OBJECTIVE: Pulmonary artery smooth muscle cells (PASMCs) from neprilysin (NEP) null mice exhibit a synthetic phenotype and increased activation of Rho GTPases compared with their wild-type counterparts. Although Rho GTPases are known to promote a contractile SMC phenotype, we hypothesize that their sustained activity decreases SM-protein expression in these cells. APPROACH AND RESULTS: PASMCs isolated from...
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