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Article

Neprilysin regulates pulmonary artery smooth muscle cell phenotype through a platelet-derived growth factor receptor-dependent mechanism.

Hypertension (Dallas, Tex. : 1979) - 1 Apr 2013

Karoor Vijaya, Oka Masahiko, Walchak Sandra J, Hersh Louis B, Miller York E, Dempsey Edward C

Abstract excerpt

Reduced neprilysin (NEP), a cell surface metallopeptidase, which cleaves and inactivates proinflammatory and vasoactive peptides, predisposes the lung vasculature to exaggerated remodeling in response to hypoxia. We hypothesize that loss of NEP in pulmonary artery smooth muscle cells results in increased migration and proliferation. Pulmonary artery smooth muscle cells isolated from NEP(-/-) mice exhibited...

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Source

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Identifiers

PMID: 23381789
DOI: 10.1161/HYPERTENSIONAHA.111.199588
PMCID: PMC3667616

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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