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Article

Smooth muscle cell-specific transcription is regulated by nuclear localization of the myocardin-related transcription factors.

American journal of physiology. Heart and circulatory physiology - 1 Feb 2007

Hinson Jeremiah S, Medlin Matthew D, Lockman Kashelle, Taylor Joan M, Mack Christopher P

Abstract excerpt

On the basis of our previous studies on RhoA signaling in smooth muscle cells (SMC), we hypothesized that RhoA-mediated nuclear translocalization of the myocardin-related transcription factors (MRTFs) was important for regulating SMC phenotype. MRTF-A protein and MRTF-B message were detected in aortic SMC and in many adult mouse organs that contain a large SMC component. Both MRTFs upregulated SMC-specific...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16997888
DOI: 10.1152/ajpheart.00864.2006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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