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Article

Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2013

Wu Jiao-Hui, Fanaroff Alexander C, Sharma Krishn C, Smith Liisa S, Brian Leigh, Eipper Betty A, Mains Richard E, Freedman Neil J, Zhang Lisheng

Abstract excerpt

OBJECTIVE: Kalirin is a multifunctional protein that contains 2 guanine nucleotide exchange factor domains for the GTPases Rac1 and RhoA. Variants of KALRN have been associated with atherosclerosis in humans, but Kalirin's activity has been characterized almost exclusively in the central nervous system. We therefore tested the hypothesis that Kalirin functions as a Rho-guanine nucleotide exchange factor in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to p21-Activated Kinases

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Share to rac1 GTP-Binding Protein

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Source

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Identifiers

PMID: 23288169
DOI: 10.1161/ATVBAHA.112.300234
PMCID: PMC3638886

Genes

KALRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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