Article
Smooth Muscle-Alpha Actin Inhibits Vascular Smooth Muscle Cell Proliferation and Migration by Inhibiting Rac1 Activity.
PloS one - 1 Jan 2016
Chen Lihua, DeWispelaere Allison, Dastvan Frank, Osborne William R A, Blechner Christine, Windhorst Sabine, Daum Guenter
Abstract excerpt
Smooth muscle alpha-actin (SMA) is a marker for the contractile, non-proliferative phenotype of adult smooth muscle cells (SMCs). Upon arterial injury, expression of SMA and other structural proteins decreases and SMCs acquire a pro-migratory and proliferative phenotype. To what extent SMA regulates migration and proliferation of SMCs is unclear and putative signaling pathways involved remain to be elucidated....
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