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Article

Loss of p53 attenuates the contribution of IL-6 deletion on suppressed tumor progression and extended survival in Kras-driven murine lung cancer.

PloS one - 1 Jan 2013

Tan Xiaohong, Carretero Julian, Chen Zhao, Zhang Jishuai, Wang Yanxiao, Chen Jicheng, Li Xiubin, Ye Hui, Tang Chuanhao, Cheng Xuan, Hou Ning, Yang Xiao, Wong Kwok-Kin

Abstract excerpt

Interleukin-6 (IL-6) is involved in lung cancer tumorigenesis, tumor progression, metastasis, and drug resistance. Previous studies show that blockade of IL-6 signaling can inhibit tumor growth and increase drug sensitivity in mouse models. Clinical trials in non-small cell lung cancer (NSCLC) reveal that IL-6 targeted therapy relieves NSCLC-related anemia and cachexia, although other clinical effects require...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24260500
DOI: 10.1371/journal.pone.0080885
PMCID: PMC3829911

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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