Article
IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras-Mutant Lung Cancer.
Cancer research - 1 Jun 2016
Caetano Mauricio S, Zhang Huiyuan, Cumpian Amber M, Gong Lei, Unver Nese, Ostrin Edwin J, Daliri Soudabeh, Chang Seon Hee, Ochoa Cesar E, Hanash Samir, Behrens Carmen, Wistuba Ignacio I, Sternberg Cinthya, Kadara Humam, Ferreira Carlos Gil, Watowich Stephanie S, Moghaddam Seyed Javad
Abstract excerpt
Activating mutations of K-ras are the most common oncogenic alterations found in lung cancer. Unfortunately, attempts to target K-ras-mutant lung tumors have thus far failed, clearly indicating the need for new approaches in patients with this molecular profile. We have previously shown NF-κB activation, release of IL6, and activation of its responsive transcription factor STAT3 in K-ras-mutant lung tumors, which...
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