Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD44 promotes Kras-dependent lung adenocarcinoma.

Oncogene - 24 Oct 2013

Zhao P, Damerow M S, Stern P, Liu A H, Sweet-Cordero A, Siziopikou K, Neilson J R, Sharp P A, Cheng C

Abstract excerpt

Kras-induced non-small-cell lung adenocarcinoma is the major subtype of lung cancers and is associated with poor prognosis. Using a lung cancer mouse model that expresses a cre-mediated KrasG12D mutant, we identified a critical role for the cell surface molecule CD44 in mediating cell proliferation downstream of oncogenic Kras signaling. The deletion of CD44 attenuates lung adenocarcinoma formation and prolongs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Adenocarcinoma of Lung
Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Hyaluronan Receptors

Share to Mitogen-Activated Protein Kinases

Share to Molecular Targeted Therapy

Share to Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed Open full text

Identifiers

PMID: 23208496
DOI: 10.1038/onc.2012.542
PMCID: PMC4227610

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD44 promotes Kras-dependent lung adenocarcinoma.PMID 23208496Read ↗

The genetics and biology of KRAS in lung cancer.Semantic proximity Read ↗

Mutationally activated PIK3CA(H1047R) cooperates with BRAF(V600E) to promote lung cancer progression.Semantic proximity Read ↗

CUL4B functions as a tumor suppressor in KRAS-driven lung tumors by inhibiting the recruitment of myeloid-derived suppressor cells.Semantic proximity Read ↗

Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy.Semantic proximity Read ↗

Modeling K-Ras-driven lung adenocarcinoma in mice: preclinical validation of therapeutic targets.Semantic proximity Read ↗

PIK3CAH1047R Accelerates and Enhances KRASG12D-Driven Lung TumorigenesisSemantic proximity Read ↗

Dual-specific phosphatase 5 (DUSP5), upregulated in lung adenocarcinoma, as a potential therapeutic target for lung cancer.Semantic proximity Read ↗

Overexpression of CD44 is associated with the occurrence and migration of non-small cell lung cancerSemantic proximity Read ↗

LIN28B enhanced tumorigenesis in an autochthonous KRASG12V-driven lung carcinoma mouse model.Semantic proximity Read ↗

PKCε Is Required for KRAS-Driven Lung Tumorigenesis.Semantic proximity Read ↗

BCL6 is regulated by the MAPK/ELK1 axis and promotes KRAS-driven lung cancer.Semantic proximity Read ↗

Dispensable role of CCL28 in Kras-mutated non-small cell lung cancer mouse models.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.