Article
Comparative Genomic Analysis of Two Clonally Related Multidrug Resistant Mycobacterium tuberculosis by Single Molecule Real Time Sequencing.
Frontiers in cellular and infection microbiology - 1 Jan 2017
Leung Kenneth Siu-Sing, Siu Gilman Kit-Hang, Tam Kingsley King-Gee, To Sabrina Wai-Chi, Rajwani Rahim, Ho Pak-Leung, Wong Samson Sai-Yin, Zhao Wei W, Ma Oliver Chiu-Kit, Yam Wing-Cheong
Abstract excerpt
Background: Multidrug-resistant tuberculosis (MDR-TB) is posing a major threat to global TB control. In this study, we focused on two consecutive MDR-TB isolated from the same patient before and after the initiation of anti-TB treatment. To better understand the genomic characteristics of MDR-TB, Single Molecule Real-Time (SMRT) Sequencing and comparative genomic analyses was performed to identify mutations that...
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