Article
Single nucleotide polymorphisms may explain the contrasting phenotypes of two variants of a multidrug-resistant Mycobacterium tuberculosis strain.
Tuberculosis (Edinburgh, Scotland) - 1 Mar 2017
Bigi María Mercedes, Lopez Beatriz, Blanco Federico Carlos, Sasiain María Del Carmen, De la Barrera Silvia, Marti Marcelo A, Sosa Ezequiel Jorge, Fernández Do Porto Darío Augusto, Ritacco Viviana, Bigi Fabiana, Soria Marcelo Abel
Abstract excerpt
Globally, about 4.5% of new tuberculosis (TB) cases are multi-drug-resistant (MDR), i.e. resistant to the two most powerful first-line anti-TB drugs. Indeed, 480,000 people developed MDR-TB in 2015 and 190,000 people died because of MDR-TB. The MDR Mycobacterium tuberculosis M family, which belongs to the Haarlem lineage, is highly prosperous in Argentina and capable of building up further drug resistance without...
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