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Article

A TEL-JAK2 Fusion Protein with Constitutive Kinase Activity in Human Leukemia

14 Nov 1997

Abstract excerpt

The Janus family of tyrosine kinases (JAK) plays an essential role in development and in coupling cytokine receptors to downstream intracellular signaling events. A t(9;12)(p24;p13) chromosomal translocation in a T cell childhood acute lymphoblastic leukemia patient was characterized and shown to fuse the 3' portion of JAK2 to the 5' region of TEL, a gene encoding a member of the ETS transcription factor family....

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Share to Chronic Myeloid Leukemia Treatments
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Identifiers

PMID: 9360930
DOI: 10.1126/science.278.5341.1309

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Related research

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A TEL-JAK2 Fusion Protein with Constitutive Kinase Activity in Human LeukemiaPMID 9360930Read ↗

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TEL-JAK2 constitutively activates the extracellular signal-regulated kinase (ERK), stress-activated protein/Jun kinase (SAPK/JNK), and p38 signaling pathways.Semantic proximity Read ↗

Pre-TCR expression cooperates with TEL-JAK2 to transform immature thymocytes and induce T-cell leukemiaSemantic proximity Read ↗

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The Role of Signal Transducer and Activator of Transcription Factors in LeukemogenesisSemantic proximity Read ↗

Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12)Semantic proximity Read ↗

Jak2: normal function and role in hematopoietic disorders.Semantic proximity Read ↗

Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia.Semantic proximity Read ↗

Fusion of TEL, the ETS-Variant Gene 6 (ETV6), to the Receptor-Associated Kinase JAK2 as a Result of t(9; 12) in a Lymphoid and t(9; 15; 12) in a Myeloid LeukemiaSemantic proximity Read ↗

Fusion of TEL, the ETS-Variant Gene 6 (ETV6), to the Receptor-Associated Kinase JAK2 as a Result of t(9; 12) in a Lymphoid and t(9; 15; 12) in a Myeloid LeukemiaSemantic proximity Read ↗

JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies.Semantic proximity Read ↗

Alternative TEL-JAK2 fusions associated with T-cell acute lymphoblastic leukemia and atypical chronic myelogenous leukemia dissected in zebrafish.Semantic proximity Read ↗

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