Article
STAT3 mutations identified in human hematologic neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model.
Haematologica - 1 Nov 2013
Couronné Lucile, Scourzic Laurianne, Pilati Camilla, Della Valle Véronique, Duffourd Yannis, Solary Eric, Vainchenker William, Merlio Jean-Philippe, Beylot-Barry Marie, Damm Frederik, Stern Marc-Henri, Gaulard Philippe, Lamant Laurence, Delabesse Eric, Merle-Beral Hélène, Nguyen-Khac Florence, Fontenay Michaëla, Tilly Hervé, Bastard Christian, Zucman-Rossi Jessica, Bernard Olivier A, Mercher Thomas
Abstract excerpt
STAT3 protein phosphorylation is a frequent event in various hematologic malignancies and solid tumors. Acquired STAT3 mutations have been recently identified in 40% of patients with T-cell large granular lymphocytic leukemia, a rare T-cell disorder. In this study, we investigated the mutational...
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