Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biochemical and structural characterization of a novel cooperative binding mode by Pit-1 with CATT repeats in the macrophage migration inhibitory factor promoter.

Nucleic acids research - 25 Jan 2018

Agarwal Sorabh, Cho Thomas Yoonsang

Abstract excerpt

Overexpression of the proinflammatory cytokine macrophage migration inhibitory factor (MIF) is linked to a number of autoimmune diseases and cancer. MIF production has been correlated to the number of CATT repeats in a microsatellite region upstream of the MIF gene. We have characterized the interaction of pituitary-specific positive transcription factor 1 (Pit-1) with a portion of the MIF promoter region...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fluorescence Polarization
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intramolecular Oxidoreductases

Share to Macrophage Migration-Inhibitory Factors

Share to Microsatellite Repeats

Share to Oligonucleotides

Share to Promoter Regions, Genetic

Share to Transcription Factor Pit-1

Source

Open in PubMed Open full text

Identifiers

PMID: 29186613
DOI: 10.1093/nar/gkx1183
PMCID: PMC5778499

Genes

MIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biochemical and structural characterization of a novel cooperative binding mode by Pit-1 with CATT repeats in the macrophage migration inhibitory factor promoter.PMID 29186613Read ↗

Genotyping Two Promoter Polymorphisms in the MIF Gene: A -794 CATT5-8 Microsatellite Repeat and a -173 G/C SNP.Semantic proximity Read ↗

A small-molecule allele-selective transcriptional inhibitor of the MIF immune susceptibility locus.Semantic proximity Read ↗

The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions.Semantic proximity Read ↗

Quantitative high-throughput analysis of transcription factor binding specificities.Semantic proximity Read ↗

Combined pituitary hormone deficiency due to the F135C human Pit-1 (pituitary-specific factor 1) gene mutation: functional and structural correlates.Semantic proximity Read ↗

Ras signaling and transcriptional synergy at a flexible Ets-1/Pit-1 composite DNA element is defined by the assembly of selective activation domains.Semantic proximity Read ↗

Sequence-specific recognition of DNA by hydrophobic, alanine-rich mutants of the basic region/leucine zipper motif investigated by fluorescence anisotropy.Semantic proximity Read ↗

Imaging the localized protein interactions between Pit-1 and the CCAAT/enhancer binding protein alpha in the living pituitary cell nucleus.Semantic proximity Read ↗

Non-independence of Mnt repressor-operator interaction determined by a new quantitative multiple fluorescence relative affinity (QuMFRA) assay.Semantic proximity Read ↗

Structure-based mutational analysis of ICAT residues mediating negative regulation of β-catenin co-transcriptional activity.Semantic proximity Read ↗

Non-attendance at general practices and outpatient clinicsSemantic proximity Read ↗

A PIT-1 homeodomain mutant blocks the intranuclear recruitment of the CCAAT/enhancer binding protein alpha required for prolactin gene transcription.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.