Article
Imaging the localized protein interactions between Pit-1 and the CCAAT/enhancer binding protein alpha in the living pituitary cell nucleus.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 2003
Day Richard N, Voss Ty C, Enwright John F, Booker Cynthia F, Periasamy Ammasi, Schaufele Fred
Abstract excerpt
The homeodomain protein Pit-1 cooperates with the basic-leucine zipper protein CCAAT/enhancer binding protein alpha (C/EBPalpha) to control pituitary-specific prolactin gene transcription. We previously observed that C/EBPalpha was concentrated in regions of centromeric heterochromatin in pituitary GHFT1-5 cells and that coexpressed Pit-1 redistributed C/EBPalpha to the subnuclear sites occupied by Pit-1. Here,...
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