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Article

Structure-based mutational analysis of ICAT residues mediating negative regulation of β-catenin co-transcriptional activity.

PloS one - 1 Jan 2017

Domingues Mélanie J, Martinez-Sanz Juan, Papon Laura, Larue Lionel, Mouawad Liliane, Bonaventure Jacky

Abstract excerpt

ICAT (Inhibitor of β-CAtenin and TCF) is a small acidic protein that negatively regulates β-catenin co-transcriptional activity by competing with TCF/LEF factors in their binding to β-catenin superhelical core. In melanoma cells, ICAT competes with LEF1 to negatively regulate the M-MITF and NEDD9 target genes. The structure of ICAT consists of two domains: the 3-helix bundle N-terminal domain binds to β-catenin...

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Share to beta Catenin
Share to Binding, Competitive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Lymphoid Enhancer-Binding Factor 1

Share to Melanocytes

Share to Microphthalmia-Associated Transcription Factor

Share to Protein Interaction Domains and Motifs

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 28273108
DOI: 10.1371/journal.pone.0172603
PMCID: PMC5342195

Genes

MITF
NEDD9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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