A small-molecule allele-selective transcriptional inhibitor of the MIF immune susceptibility locus.

doi:10.1016/j.jbc.2024.107443

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Article

A small-molecule allele-selective transcriptional inhibitor of the MIF immune susceptibility locus.

The Journal of biological chemistry - 1 Jul 2024

Li Jia, Leng Lin, Pantouris Georgios, Manjula Ramu, Piecychna Marta, Abriola Laura, Hu Buqu, Lolis Elias, Armstrong Michelle E, Donnelly Seamas C, Bucala Richard

Abstract excerpt

Functional variants of the gene for the cytokine macrophage migration inhibitory factor (MIF) are defined by a 4-nucleotide promoter microsatellite (-794 CATT5-8, rs5844572) and confer risk for autoimmune, infectious, and oncologic diseases. We describe herein the discovery of a prototypic, small molecule inhibitor of MIF transcription with selectivity for high microsatellite repeat number and correspondingly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38838773
DOI: 10.1016/j.jbc.2024.107443
PMCID: PMC11259703

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